Loracarbef

Loracarbef

Loracarbef
Systematic (IUPAC) name
(6R,7S)-7-[[(2S)-2-amino-2-phenylacetyl]amino]-3-chloro-8-oxo-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
Clinical data
Trade names Lorabid
AHFS/Drugs.com
MedlinePlus
Legal status
?
Pharmacokinetic data
Protein binding 25%
Identifiers
CAS number  YesY
ATC code J01
PubChem
DrugBank
ChemSpider  YesY
UNII  N
KEGG  YesY
ChEMBL  N
Chemical data
Formula C16H16ClN3O4 
Mol. mass 349.769 g/mol
 N   

Loracarbef is an antibiotic.[1] It is a carbacephem, but it is sometimes grouped together with the second-generation cephalosporin antibiotics. Loracarbef is a synthetic "carba" analog of cefaclor, and is more stable chemically.

Contents

  • History 1
  • Side effects 2
  • References 3
  • External links 4

History

Loracarbef received FDA approval in 1991 and it was marketed under the trade name Lorabid. Its use was discontinued in 2006.

Side effects

Diarrhea is the most common adverse effect with loracarbef. Side effects are more frequently seen with children under the age of twelve.

References

  1. ^ Biedenbach DJ, Jones RN (February 1994). "Predictive accuracy of disk diffusion test for Proteus vulgaris and Providencia species against five newer orally administered cephalosporins, cefdinir, cefetamet, cefprozil, cefuroxime, and loracarbef". J. Clin. Microbiol. 32 (2): 559–62.  

External links

  • RxList.com - Loracarbef