|MAX interactor 1, dimerization protein|
|Symbols||; MAD2; MXD2; MXI; bHLHc11|
|RNA expression pattern|
MAX-interacting protein 1 is a protein that in humans is encoded by the MXI1 gene. Expression of the c-myc gene, which produces an oncogenic transcription factor, is tightly regulated in normal cells but is frequently deregulated in human cancers. The protein encoded by this gene is a transcriptional repressor thought to negatively regulate MYC function, and is therefore a potential tumor suppressor. This protein inhibits the transcriptional activity of MYC by competing for MAX, another basic helix-loop-helix protein that binds to MYC and is required for its function. Defects in this gene are frequently found in patients with prostate tumors. Three alternatively spliced transcripts encoding different isoforms have been described. Additional alternatively spliced transcripts may exist but the products of these transcripts have not been verified experimentally.
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- Prochownik EV, Eagle Grove L, Deubler D et al. (1999). "Commonly occurring loss and mutation of the MXI1 gene in prostate cancer". Genes Chromosomes Cancer 22 (4): 295–304.
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- Benson LQ, Coon MR, Krueger LM et al. (1999). "Expression of MXI1, a Myc antagonist, is regulated by Sp1 and AP2". J. Biol. Chem. 274 (40): 28794–802.
- Taj MM, Tawil RJ, Engstrom LD et al. (2001). "Mxi1, a Myc antagonist, suppresses proliferation of DU145 human prostate cells". Prostate 47 (3): 194–204.
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- MXI1 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
- FactorBook Mxi1