Magnolol

Magnolol

Magnolol[1]
Names
IUPAC name
4-Allyl-2-(5-allyl-2-hydroxy-phenyl)phenol
Other names
Dehydrodichavicol
5,5'-Diallyl-2,2'-dihydroxybiphenyl
5,5'-Diallyl-2,2'-biphenyldiol
Identifiers
 YesY
ChEMBL  N
ChemSpider  N
Jmol-3D images Image
PubChem
Properties
C18H18O2
Molar mass 266.334
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).

Magnolol is an lignan. It is a bioactive compound found in the bark of the Houpu magnolia (Magnolia officinalis) or in M. grandiflora.[2] The compound exists at the level of a few percent in the bark of species of magnolia, the extracts of which have been used in traditional Chinese and Japanese medicine. In addition to magnolol, related lignans occur in the extracts including honokiol, which is an isomer of magnolol.

Bioactivity

It is known to act on the GABAA receptors in rat cells in vitro[3] as well as having antifungal properties.[4] It is also known to act as agonist of PPARgamma, nuclear receptor that is current pharmacological target for the treatment of diabetes type 2.[5] Magnolol has a number of osteoblast-stimulating and osteoclast-inhibiting activities in cell culture and has been suggested as a candidate for screening for anti-osteoporosis activity.[6] It has anti-periodontal disease activity in a rat model.[7] Structural analogues has been studied and found to be strong allosteric modulators of GABAA.[8]

References

  1. ^ Magnolol at Sigma-Aldrich
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Further reading

  • Chaya Venkat, "Sitting under a Magnolia Tree, Mint Julep in Hand" (depicts incorrect structure of magnolol)