Masoprocol

Masoprocol

Masoprocol
Systematic (IUPAC) name
4-[(2R,3S)-4-(3,4-dihydroxyphenyl)-2,3-dimethylbutyl]benzene-1,2-diol
Clinical data
Trade names Actinex
AHFS/Drugs.com
Pregnancy
category
  • US: B (No risk in non-human studies)
Routes of
administration
Topical
Pharmacokinetic data
Bioavailability Very low
Identifiers
CAS Registry Number  Y
ATC code L01
PubChem CID:
IUPHAR/BPS
DrugBank  Y
ChemSpider  Y
UNII  Y
ChEBI  N
ChEMBL  N
Chemical data
Formula C18H22O4
Molecular mass 302.365 g/mol
 N   

Masoprocol is an antineoplastic drug used to treat skin growths caused by sun exposure. A form of nordihydroguaiaretic acid that is taken by mouth is being studied in the treatment of prostate cancer.

Also called nordihydroguaiaretic acid, NDGA, and actinex.

Mechanism

Nordihydroguaiaretic acid is an antioxidant, and it may block certain enzymes needed for tumor growth.

It is a lipoxygenase inhibitor.[1]

References

  1. ^ "Masoprocol decreases rat lipolytic activity by decreasing the phosphorylation of HSL". Am. J. Physiol. Endocrinol. Metab. 279 (3): E593–600. September 2000.  

External links

  • MedlinePlus Drug Information
  • Actinex entry in the public domain NCI Cancer Dictionary