Metrifonate

Metrifonate

Metrifonate
Systematic (IUPAC) name
(RS)-Dimethyl (2,2,2-trichloro-1-hydroxyethyl)phosphonate
Clinical data
AHFS/Drugs.com
Legal status
?
Pharmacokinetic data
Half-life 3 hours
Identifiers
CAS number  YesY
ATC code P02 QP52 QP53
PubChem
ChemSpider
UNII  YesY
KEGG  YesY
ChEBI  YesY
Synonyms Trichlorphon
Chemical data
Formula C4H8Cl3O4P 
Mol. mass 257.436 g/mol
 YesY   

Metrifonate (acetylcholinesterase inhibitor.[1] It is a prodrug which is activated non-enzymatically into 2,2-dichlorovinyl dimethyl phosphate (DDVP).

It is used as an insecticide.

It can be used to treat schistosomiasis caused by Schistoma haematobium but is no longer commercially available.[2]

It has been proposed for use in treatment of Alzheimer's disease, but use for that purpose is not currently recommended.[3]

References

  1. ^ "NLH - Neurological Conditions - Metrifonate for Alzheimer's disease". 
  2. ^ Ross A.G.P., Bartley P.B., Sleigh A.C., Olds G.R., Li Y., Williams G.M., and McManus D.P. (2002). "Schistosomiasis". The New England Journal of Medicine 346 (16): 1212–1220.  
  3. ^ López-Arrieta J, Schneider L (2008). López-Arrieta, Jess, ed. "Metrifonate for Alzheimer's disease". Cochrane Database of Systematic Reviews (1): CD003155.