Morphiceptin

Morphiceptin

Morphiceptin
Identifiers
CAS number  YesY
PubChem
ChemSpider  N
Jmol-3D images Image 1
Properties
Molecular formula C28H35N5O5
Molar mass 521.6 g/mol
Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
 N   YesY/N?)

Morphiceptin is a tetrapeptide (Tyr-Pro-Phe-Pro-NH2) that is a selective μ-opioid receptor agonist. It is derived from β-casomorphin and has over 1,000 times selectivity for μ- over δ-opioid receptors. When injected intracerebroventricularly (into the ventricular system of the brain), morphiceptin had an analgesic ED50 of 1.7 nmol per animal. The analgesic effects of morphiceptin were reversed by naloxone, meaning that the analgesic effect is mediated by the μ-opioid receptor.[2]

See also

References

  1. ^ "Morphiceptin". Morphiceptin. ChemBase. Retrieved 1 August 2011. 
  2. ^ Chang, K (3 May 1982). "Analgesic activity of intracerebroventricular administration of morphiceptin and β-casomorphins: Correlation with the morphine (μ) receptor binding affinity". Life Sciences 30 (18): 1547–1551.