Moxazocine

Moxazocine

Moxazocine
Systematic (IUPAC) name
(1S,9R,13S)-10-(cyclopropylmethyl)-13-methoxy-1-methyl-10-azatricyclo[7.3.1.02,7]trideca-2,4,6-trien-4-ol
Clinical data
Legal status
?
Identifiers
CAS number
ATC code ?
ChemSpider
Chemical data
Formula C18H25NO2 
Mol. mass 287.397 g/mol

Moxazocine (BL-4566) is an opioid analgesic of the benzomorphan family which was never marketed.[1] It acts as a partial agonist or mixed agonist/antagonist of the opioid receptors and binds preferentially to the κ-opioid receptor.[2] Despite its failure to reach the market, clinical studies demonstrated moxazocine to be approximately 10x as potent by weight as morphine as an analgesic.[3]

See also

References

  1. ^ Dictionary of Pharmacological Agents Volume 2. CRC Press. p. 1382.  
  2. ^ Hayes AG, Sheehan MJ, Tyers MB (August 1987). "Differential sensitivity of models of antinociception in the rat, mouse and guinea-pig to mu- and kappa-opioid receptor agonists".  
  3. ^ Dobkin, Allen B; Esposito, Barbara F; Noveck, Robert J; Caruso, Frank S (October 1977). "Moxazocine and morphine in patients with severe postoperative pain". Current Therapeutic Research. 22(4): 469–478.