Muscarinic acetylcholine receptor m1
|Cholinergic receptor, muscarinic 1|
The muscarinic acetylcholine receptor M1, also known as the cholinergic receptor, muscarinic 1, is a muscarinic receptor.
It is predominantly found bound to G proteins of class Gq that use upregulation of phospholipase C and, therefore, inositol trisphosphate and intracellular calcium as a signalling pathway. A receptor so bound would not be susceptible to CTX or PTX. However, Gi (causing a downstream decrease in cAMP) and Gs (causing an increase in cAMP) have also been shown to be involved in interactions in certain tissues, and so would be susceptible to PTX and CTX respectively.
- EPSP in autonomic ganglia
- secretion from salivary glands
- gastric acid secretion from stomach
- In CNS (memory?)
- vagally-induced bronchoconstriction
- McN-A-343 - mixed M1/M4 agonist
- L-689,660 - mixed M1/M3 agonist
- 77-LH-28-1 - brain penetrant selective M1 allosteric agonist
- mamba toxin muscarinic toxin 7 (MT7)
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