Muscarinic acetylcholine receptor M5

Muscarinic acetylcholine receptor M5

Cholinergic receptor, muscarinic 5
Identifiers
CHRM5 Gene
RNA expression pattern

The human muscarinic acetylcholine receptor M5, encoded by the cyclic AMP levels and downregulate the activity of protein kinase A (PKA).

Ligands

No highly selective agonists or antagonists for the M5 receptor have been discovered as of 2009, but several non-selective muscarinic agonists and antagonists have significant affinity for M5.

Agonists

  • Milameline ((E)-1,2,5,6-Tetrahydro-1-methyl-3-pyridinecarboxaldehyde-O-methyloxime, CAS# 139886-32-1)
  • Sabcomeline

Positive allosteric modulators

  • VU-0238429: EC50 = 1.16 μM; >30-fold selectivity versus M1 and M3, inactive at M2 and M4.[1]

Antagonists

See also

References

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.