NRL (gene)

NRL (gene)

Neural retina leucine zipper
Identifiers
Symbols  ; D14S46E; NRL-MAF; RP27
External IDs GeneCards:
RNA expression pattern
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)
RefSeq (protein)
Location (UCSC)
PubMed search

Neural retina-specific leucine zipper protein is a protein that in humans is encoded by the NRL gene.[1][2][3] This gene encodes a basic motif-leucine zipper transcription factor of the Maf subfamily. The encoded protein is conserved among vertebrates and is a critical intrinsic regulator of photoceptor development and function. Mutations in this gene have been associated with retinitis pigmentosa and retinal degenerative diseases.[3]

See also

References

  1. ^ Yang-Feng TL, Swaroop A (Dec 1992). "Neural retina-specific leucine zipper gene NRL (D14S46E) maps to human chromosome 14q11.1-q11.2". Genomics 14 (2): 491–2.  
  2. ^ Bessant DA, Payne AM, Mitton KP, Wang QL, Swain PK, Plant C, Bird AC, Zack DJ, Swaroop A, Bhattacharya SS (Apr 1999). "A mutation in NRL is associated with autosomal dominant retinitis pigmentosa". Nat Genet 21 (4): 355–6.  
  3. ^ a b "Entrez Gene: NRL neural retina leucine zipper". 

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.