|Systematic (IUPAC) name|
|Mol. mass||425.562 g/mol|
The drug is one of a series of similar structures invented at Upjohn. An earlier compound known as U-11,555 is related to Nafoxidine was found to cause photosensitivity in human volunteers.
The synthesis depicted is more modern, but also see Lasofoxifene for an earlier synthesis.
- 6-Methoxytetralone (Cas Number: 1078-19-9).
- Pyridinium tribromide (Pyridinium bromide perbromide)
- Suzuki–Miyaura reaction (Suzuki reaction)
- Steinbaum, F. L.; De Jager, R.; Krakoff, I. (1978). "Clinical trial of nafoxidine in advanced breast cancer". Medical and Pediatric Oncology 4 (2): 123–126.
- Lednicer,, D.; Babcock, J.C.; Marlatt, P.E.; Lyster, S.C.; Duncan, G.W. (1965). "Mammalian Antifertility Agents. I. Derivatives of 2,3-Diphenylindenes". J. Med. Chem. 8 (1): 52–57.