CAS number 84845-75-0 YesY
PubChem 3033952
KEGG D07072 YesY
MeSH Niperotidine
ATC code BA05
Jmol-3D images Image 1
Molecular formula C20H26N4O5S
Molar mass 434.50924
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Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Niperotidine is a histamine antagonist selective for the H2 subtype. It was trialled as a treatment for excessive gastric acidity,[1] but withdrawn after human trials showed liver damage.[2]

Adverse effects

Antacid preparations such as niperotidine by suppressing acid mediated break down of proteins, leads to an elevated risk of developing food or drug allergies. This happens due to undigested proteins then passing into the gastrointestinal tract where sensitisation occurs. It is unclear whether this risk occurs with only long-term use or with short-term use as well.[3]