CAS number  YesY
ChemSpider  N
KEGG  YesY[]
ATCvet code QP53
Jmol-3D images Image 1
Molecular formula C11H15ClN4O2
Molar mass 270.72 g/mol
Melting point 72 °C (162 °F; 345 K)[1]
Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
 N   YesY/N?)

Nitenpyram is an insecticide used in agriculture and veterinary medicine to kill external parasites of livestock and pets. It is a neonicotinoid, a neurotoxin that blocks neural messages in the central nervous system of insects, causing rapid death.

It is used orally with dogs and cats to control fleas. After ingestion, it begins killing fleas within 30 minutes and kills all adult fleas within 4 hours. The effects of nitenpyram last approximately 24–48 hours. Nitenpyram is safe to use on puppies and kittens as young as four weeks old if they weigh at least 2 pounds (0.91 kg). Panting and excitement have been noted in cats within 2 hours of administration. In heavily infested animals, it can cause extreme itching as the fleas die.

Nitenpyram does not kill insect eggs and has no long-term activity. Thus, it is not effective as a long-term flea preventative. It is usually used to kill nymph and adult fleas quickly on an infested animal, and combined with a longer-term flea preventative like fipronil or lufenuron to prevent reinfestation.

External links

  • Pesticide Properties Database (PPDB) record for Nitenpyram
  • Capstar website
  • Material Safety Data Sheet (MSDS) for Nitenpyram
  • Freedom of Information summary (NADA 141-053), US Food and Drug Administration


  1. ^ Safety (MSDS) data for nitenpyram