Noribogaine

Noribogaine

Noribogaine
Systematic (IUPAC) name
12-Hydroxyibogamine
Clinical data
Legal status
Routes Metabolite of Iboga-alkaloid(s?) Ibogaine.
Identifiers
CAS number  N
ATC code ?
PubChem
ChemSpider  YesY
Chemical data
Formula C19H24N2O 
Mol. mass 296.407 g/mol
 N   

Noribogaine, or 12-hydroxyibogamine, is the principal psychoactive metabolite of the psychedelic drug ibogaine. It is thought to be involved in the anti-addictive effects of ibogaine-containing plant extracts.[1][2][3]

See also

  • 18-Methoxycoronaridine, a pharmaceutical derivative of ibogaine
  • Salvinorin A, a psychedelic dissociative present in the leaves of Salvia divinorum
  • Voacangine, an alkaloid present in the root bark of T. iboga and other plants

References

  1. ^ Glick SD, Maisonneuve IS (May 1998). "Mechanisms of antiaddictive actions of ibogaine". Annals of the New York Academy of Sciences 844: 214–26.  
  2. ^ Baumann MH, Pablo J, Ali SF, Rothman RB, Mash DC (2001). "Comparative neuropharmacology of ibogaine and its O-desmethyl metabolite, noribogaine". The Alkaloids. Chemistry and Biology 56: 79–113.  
  3. ^ Kubiliene A, Marksiene R, Kazlauskas S, Sadauskiene I, Razukas A, Ivanov L (2008). "Acute toxicity of ibogaine and noribogaine". Medicina (Kaunas, Lithuania) 44 (12): 984–8.