Opsin 1 (cone pigments), long-wave-sensitive
Available structures
PDB Ortholog search: RCSB
RNA expression pattern

Red-sensitive opsin is a protein that in humans is encoded by the OPN1LW gene.[1]

This gene encodes for a light absorbing visual pigment of the opsin gene family. The encoded protein is called red cone photopigment or long-wavelength sensitive opsin, because its main response is for red color wavelengths. Nevertheless, it has a secondary response in the violet high frequencies[2]

Opsins are G-protein coupled receptors with seven transmembrane domains, an N-terminal extracellular domain, and a C-terminal cytoplasmic domain. This gene and the medium-wavelength opsin gene are tandemly arrayed on the X chromosome and frequent unequal recombination and gene conversion may occur between these sequences. X chromosomes may have fusions of the medium- and long-wavelength opsin genes or may have more than one copy of these genes. Defects in this gene are the cause of partial, protanopic colorblindness.[1]

See also


External links

  • GeneReviews/NIH/NCBI/UW entry on Red-Green Color Vision Defects

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.