Oxaflozane

Oxaflozane

Oxaflozane
Systematic (IUPAC) name
4-propan-2-yl-2-[3-(trifluoromethyl)phenyl]morpholine
Clinical data
Legal status
  • Prescription only
Routes Oral
Identifiers
CAS number
ATC code N06
PubChem
ChemSpider
UNII  YesY
KEGG
Chemical data
Formula C14H18F3NO 
Mol. mass 273.29 g/mol

Oxaflozane (Conflictan) is an antidepressant and anxiolytic drug that was introduced in France in 1982 by Solvay for the treatment of depression, but has since been abandoned.[1][2] It is a prodrug to N-dealkyloxaflozane, which acts as a non-selective serotonin receptor agonist for the 5-HT1A (pKi = 7.1), 5-HT2A (pKi = 6.0), and 5-HT2C (pKi = 7.5) subtypes.[3] Oxaflozane may also have anticholinergic effects in high doses.[4]

References

  1. ^ Swiss Pharmaceutical Society (2000). Index Nominum 2000: International Drug Directory (Book with CD-ROM). Boca Raton: Medpharm Scientific Publishers. p. 766.  
  2. ^ Sittig, Marshall (1988). Pharmaceutical manufacturing encyclopedia. Park Ridge, N.J., U.S.A: Noyes Publications. p. 1122.  
  3. ^ Leysen DC (February 1999). "Selective 5-HT2C agonists as potential antidepressants". IDrugs : the Investigational Drugs Journal 2 (2): 109–20.  
  4. ^ Dutertre JP, Barbier P, Suc AL, Jonville AP, Autret E (1992). "Oxaflozane overdose in a child". Journal of Toxicology. Clinical Toxicology 30 (1): 123–6.  

Further reading

External links

  • Oxaflozane: The Merck Index
  • Oxaflozane: Martindale: The Complete Drug Reference