Oxon (chemical)

Oxon (chemical)

Parathion (left) and its oxon, paraoxon (right)

An oxon is an phosphorus-sulfur bond in the parent chemical has been replaced by a phosphorus-oxygen bond in the derivative.

Important examples of oxons can be found in the family of chlorpyrifos, diazinon, and parathion, do not manifest their main toxicity in their original form. Rather, an animal's liver replaces a phosphorus-sulfur bond with a phosphorus-oxygen bond, turning these chemicals into oxons. The oxons then inhibit an enzyme that breaks down acetylcholine, an important neurotransmitter. Acetylcholine starts to accumulate uncontrollably, wreaking havoc on the animal's nervous system.

See also