Purinergic receptor P2Y, G-protein coupled, 1
Available structures
PDB Ortholog search: RCSB
P2RY1 Gene
RNA expression pattern

P2Y purinoceptor 1 is a protein that in humans is encoded by the P2RY1 gene.[1]

The product of this gene, P2Y1 belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor functions as a receptor for extracellular ATP and ADP. In platelets binding to ADP leads to mobilization of intracellular calcium ions via activation of phospholipase C, a change in platelet shape, and probably to platelet aggregation.[2]

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Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.