PYCR1

PYCR1

Pyrroline-5-carboxylate reductase 1
PDB rendering based on 2ger.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols  ; ARCL2B; ARCL3B; P5C; P5CR; PIG45; PP222; PRO3; PYCR
External IDs GeneCards:
EC number
RNA expression pattern
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)
RefSeq (protein)
Location (UCSC)
PubMed search

Pyrroline-5-carboxylate reductase 1, mitochondrial is an enzyme that in humans is encoded by the PYCR1 gene.[1][2] This gene encodes an enzyme that catalyzes the NAD(P)H-dependent conversion of pyrroline-5-carboxylate to proline. This enzyme may also play a physiologic role in the generation of NADP(+) in some cell types. The protein forms a homopolymer and localizes to the mitochondrion. Alternate splicing results in two transcript variants encoding different isoforms.[2]

References

  1. ^
  2. ^ a b

Further reading