|Systematic (IUPAC) name|
|Biological half-life||8.6 hours|
|Excretion||Mostly renal, also biliary|
|CAS Registry Number|
|Molecular mass||333.358 g/mol|
Pefloxacin is a quinolone drug used to treat bacterial infections. Pefloxacin has not been approved for use in the United States.
- History 1
- Licensed uses 2
- Mode of action 3
- Adverse effects 4
- References 5
- External links 6
Pefloxacin was developed in 1979 and approved in France for human use in 1985.
- Uncomplicated gonococcal urethritis in males.
- Bacterial infections in the gastrointestinal system.
- Genitourinary tract infections.
- Gonorrhoeae. however this indication is no longer effective due to bacterial resistance.
Pefloxacin has been increasingly used as a veterinary medicine to treat microbial infections.
Mode of action
Pefloxacin is a broad-spectrum antibiotic that is active against both Gram-positive and Gram-negative bacteria. It functions by inhibiting DNA gyrase, a type II topoisomerase, and topoisomerase IV, which is an enzyme necessary to separate, replicated DNA, thereby inhibiting cell division.
Tendinitis and rupture, usually of the Achilles tendon, are a class-effects of the fluoroquinolones, most frequently reported with pefloxacin. The estimated risk of tendon damage during pefloxacin therapy has been estimated by the French authorities in 2000 to be 1 case per 23,130 treatment days as compared to ciprofloxacin where it has been estimated to be 1 case per 779,600.
- How Stuff Works - Cipro
- Package insert information