Transverse section of human tibial nerve. (Perineurium labeled at upper right.)
The perineurium is composed of connective tissue, which has a distinctly lamellar arrangement consisting of roughly 7-8 concentric layers. The perineurium is cellular, and is composed of perineurial cells, which are epithelioid myofibroblasts. Perineurial cells are sometimes referred to as myoepithelioid due to their epithelioid and myofibroblastoid properties including tight junctions, gap junctions, external laminae and contractility.
The perineurium is a smooth, transparent tubular membrane which may be easily separated from the fibers it encloses. In contrast, the epineurium is a tough and mechanically resistant tissue which is not easily penetrated by a needle.
- McCracken, Thomas (1999). New Atlas of Human Anatomy. China: Metro Books. pp. 96–97.
- Histology image: 1_03 at the University of Oklahoma Health Sciences Center - "Peripheral nerve"
- Anatomy photo: nervous/pns/nerve1/nerve2 - Comparative Organology at University of California, Davis - "PNS, nerve (LM, Low)"
- Histology image: 21401loa – Histology Learning System at Boston University
- Diagram at Howard
- Histology at ucla.edu