Pheniprazine

Pheniprazine

Pheniprazine
Systematic (IUPAC) name
(1-methyl-2-phenyl-ethyl)hydrazine
Clinical data
Legal status
  • Uncontrolled
Routes Oral
Identifiers
CAS number  N
ATC code None
PubChem
ChemSpider  YesY
UNII  YesY
ChEMBL  YesY
Chemical data
Formula C9H14N2 
Mol. mass 150.22 g/mol
 N   

Pheniprazine (Catron, Cavodil) is an irreversible and nonselective monoamine oxidase inhibitor (MAOI) of the hydrazine chemical class that was used as an antidepressant in the 1960s.[1][2][3] It was also used in the treatment of angina pectoris and schizophrenia.[4][5] Pheniprazine has been largely discontinued due to toxicity concerns such as jaundice, amblyopia, and optic neuritis.[6][7][8]

See also

References

  1. ^ LEAR TE, BROWNE MW, GREEVES JA (November 1962). "A controlled trial of cavodil (pheniprazine) in depression". J Ment Sci 108: 856–58.  
  2. ^ Fagervall I, Ross SB (April 1986). "Inhibition of monoamine oxidase in monoaminergic neurones in the rat brain by irreversible inhibitors".  
  3. ^ EBERSON LE, PERSSON K (July 1962). "Studies on Monoamine Oxidase Inhibitors. 1. The Autoxidation of beta-Phenylisopropylhydrazine as a Model Reaction for Irreversible Monoamine Oxidase Inhibition.". J Med Pharm Chem 91: 738–52.  
  4. ^ SANDLER G (March 1961). "Clinical evaluation of pheniprazine in angina pectoris". Br Med J 1 (5228): 792–4.  
  5. ^ WICKSTROM L, HAHN N (September 1962). "[beta-Phenylisoprophlhydrazine (Catran) in schizophrenia.]". Nord Med (in Swedish) 68: 1165–7.  
  6. ^ FENTEM PH, HOWITT G (December 1961). "Fatal jaundice after administration of pheniprazine". Br Med J 2 (5267): 1616–7.  
  7. ^ FRANDSEN E (1962). "Toxic amblyopia during antidepressant treatment with pheniprazine (Catran)". Acta Psychiatr Scand 38: 1–14.  
  8. ^ THOMSEN NJ (January 1963). "[Optic neuritis after treatment with Catran.]". Ugeskr. Laeg. (in Danish) 125: 138–9.