Phenylethylidenehydrazine

Phenylethylidenehydrazine

Phenylethylidenehydrazine
Systematic (IUPAC) name
(1E)-(2-Phenylethylidene)hydrazine
Clinical data
Legal status
  • Uncontrolled
Pharmacokinetic data
Half-life ~12 hours
Identifiers
CAS number
ATC code None
PubChem
ChemSpider
Chemical data
Formula C8H10N2 
Mol. mass 134.18 g/mol

Phenylethylidenehydrazine (PEH) is an inhibitor of the enzyme GABA transaminase (GABA-T).[1][2] It is a metabolite of the antidepressant phenelzine and is responsible for its elevation of GABA concentrations.[1] PEH likely plays a significant role in phenelzine's high efficacy in treating anxiety disorders.

See also

References

  1. ^ a b Parent MB, Master S, Kashlub S, Baker GB (January 2002). "Effects of the antidepressant/antipanic drug phenelzine and its putative metabolite phenylethylidenehydrazine on extracellular gamma-aminobutyric acid levels in the striatum".  
  2. ^ Duffy S, Nguyen PV, Baker GB (2004). "Phenylethylidenehydrazine, a novel GABA-transaminase inhibitor, reduces epileptiform activity in rat hippocampal slices". Neuroscience 126 (2): 423–32.