Phospholipase cleavage sites. Note that an enzyme that displays both PLA1 and PLA2 activities is called a Phospholipase B.

A phospholipase is an enzyme that hydrolyzes phospholipids[1] into fatty acids and other lipophilic substances. There are four major classes, termed A, B, C and D, distinguished by the type of reaction which they catalyze:

Types C and D are considered phosphodiesterases.

Phospholipase A2 acts on the intact lecithin molecule and hydrolyses the fatty acid esterified to the second carbon atom. The resulting products are lysolecithin and a fatty acid. Phospholipase A2 is an enzyme present in the venom of bees and viper snakes.[2]


  • See also 1
  • References 2
  • Further Reading 3
  • External links 4

See also


  1. ^ "phospholipase" at Dorland's Medical Dictionary
  2. ^ D. M. Vasudevan & S. Sreekumari, Textbook of Biochemistry (5th ed.)

Further Reading

  • Tappia, Paramjit S. & Dhalla, Naranjan S. (Editors): Phospholipases in Health and Disease. Springer, 2014. ISBN 978-1-4939-0463-1 [Print]; ISBN 978-1-4939-0464-8 [eBook]

External links