Pitolisant

Pitolisant

Pitolisant
Identifiers
CAS number 903576-44-3 N
PubChem 9948102
ChemSpider 8123714 YesY
Jmol-3D images Image 1
Properties
Molecular formula C17H26ClNO
Molar mass 295.85 g mol−1
 N (verify) (what is: YesY/N?)
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Pitolisant (INN) or tiprolisant (USAN) is a histamine receptor inverse agonist/antagonist selective for the H3 subtype.[1] It has stimulant and nootropic effects in animal studies,[2] and may have several medical applications, having been researched for the treatment of narcolepsy, for which it has been granted orphan drug status in the EU and US.[3][4] It is currently in clinical trials for schizophrenia and Parkinson's disease.[4][5][6]

Pitolisant was developed by Jean-Charles Schwartz and colleagues after the former discovered H3 receptors.[1] Pitolisant was the first clinically used H3 receptor inverse agonist.

References