CD59 molecule, complement regulatory protein
PDB rendering based on 1cdq.
Available structures
PDB Ortholog search: RCSB
CD59 Gene
RNA expression pattern

CD59 glycoprotein also known as MAC-inhibitory protein (MAC-IP), membrane inhibitor of reactive lysis (MIRL), or protectin is a protein that in humans is encoded by the CD59 gene.[1]

CD59 attaches to host cells via a glycophosphatidylinositol (GPI) anchor. When complement activation leads to deposition of C5b678 on host cells, CD59 can prevent C9 from polymerizing and forming the complement membrane attack complex.[2] Mutations affecting GPI that reduce expression of CD59 and decay-accelerating factor on red blood cells result in paroxysmal nocturnal hemoglobinuria.[3]

Viruses such as HIV, human cytomegalovirus and vaccinia incorporate host cell CD59 into their own viral envelope to prevent lysis by complement.[4]


Further reading

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  • Medical Subject Headings (MeSH)