RTI-32

RTI-32

RTI-32
Systematic (IUPAC) name
methyl (1R,2S,3S,5S)-3-(4-methylphenyl)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylate
Clinical data
Legal status
?
Identifiers
CAS number
ATC code ?
PubChem
Chemical data
Formula C17H23NO2 
Mol. mass 273.370 g/mol
 YesY   

(–)-2β-Carbomethoxy-3β-(4-tolyl)tropane (RTI-32, tolpane) is a phenyltropane-based cocaine analog that is important in the field of medicinal chemistry for performing SAR.

It has similar properties in vitro to related drugs such as RTI-31.[1]

Whereas the potency of RTI-31 has been quoted as being as high as 64 x cocaine, RTI-32 is not anything like this strong.

Comparison of Data
Compound DAT DA NET NA SERT 5HT ED50
Troparil 23 49.8 550 37.2 178 173 0.34
RTI-32 1.7 7.02 36 8.42 23 19.4 0.31
RTI-31 1.1 3.68 22 5.86 4.0 5.0 0.13
3'4'-xylyl 0.43 unknown 44 unknown 2.42 unknown

Further Analogues

Another good source to read is:[2]

See also

References

  1. ^ Remy P, Doder M, Lees A, Turjanski N, Brooks D. Depression in Parkinson's disease: loss of dopamine and noradrenaline innervation in the limbic system. Brain. 2005 Jun;128(Pt 6):1314-22. PMID 15716302
  2. ^ Xu, L.; Izenwasser, S.; Katz, J. L.; Kopajtic, T.; Klein-Stevens, C.; Zhu, N.; Lomenzo, S. A.; Winfield, L.; Trudell, M. L. (2002). "Synthesis and Biological Evaluation of 2-Substituted 3β-Tolyltropane Derivatives at Dopamine, Serotonin, and Norepinephrine Transporters". Journal of Medicinal Chemistry 45 (6): 1203.