RVD-Hpα

RVD-Hpα fragment of hemoglobin, alpha 1
Identifiers
Symbol HBA1
Entrez HUGO OMIM RefSeq UniProt Locus p13.3

RVD-Hpα is an endogenous neuropeptide found in human and mammalian brain, which was originally proposed to act as a selective agonist for the CB1 cannabinoid receptor. It is a 12-amino acid polypeptide having the amino acid sequence Arg-Val-Asp-Pro-Val-Asn-Phe-Lys-Leu-Leu-Ser-His and is an N-terminal extended form of hemopressin, a 9-AA polypeptide derived from the α1 subunit of hemoglobin which has previously been shown to act as a CB1 inverse agonist.[1] All three polypeptides have been isolated from various mammalian species, with RVD-Hpα being one of the more abundant neuropeptides expressed in mouse brain, and these neuropeptides represent a new avenue for cannabinoid research distinct from the previously known endogenous lipid-derived cannabinoid agonists such as anandamide.[2] Recently it was shown that RVD-Hpα (also called Pepcan-12) is an potent negative allosteric modulator at CB1 receptors, together with other newly described N-terminally extended peptides (pepcans) [3]

species RVD-Hpα sequence
human RVDPVNFKLLSH
mouse RVDPVNFKLLSH
rat RVDPVNFKfLSH
consensus RVDPVNFKxLSH

References