Retinoic acid receptor beta

Retinoic acid receptor beta

Retinoic acid receptor, beta

PDB rendering based on 1dsz.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols  ; HAP; MCOPS12; NR1B2; RRB2
External IDs IUPHAR: ChEMBL: GeneCards:
RNA expression pattern
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)
RefSeq (protein)
Location (UCSC)
PubMed search

Retinoic acid receptor beta (RAR-beta), also known as NR1B2 (nuclear receptor subfamily 1, group B, member 2) is a nuclear receptor that in humans is encoded by the RARB gene.[1][2]

Function

This gene encodes retinoic acid receptor beta, a member of the thyroid-steroid hormone receptor superfamily of nuclear transcriptional regulators. This receptor localizes to the cytoplasm and to subnuclear compartments. It binds retinoic acid, the biologically active form of vitamin A which mediates cellular signalling in embryonic morphogenesis, cell growth and differentiation. It is thought that this protein limits growth of many cell types by regulating gene expression. The gene was first identified in a hepatocellular carcinoma where it flanks a hepatitis B virus integration site. The gene expresses at least two transcript variants; one additional transcript has been described, but its full length nature has not been determined.[1]

Interactions

Retinoic acid receptor beta has been shown to interact with NR4A2.[3]

See also

References

  1. ^ a b "Entrez Gene: RARB retinoic acid receptor, beta". 
  2. ^ Mattei MG, de Thé H, Mattei JF, Marchio A, Tiollais P, Dejean A (October 1988). "Assignment of the human hap retinoic acid receptor RAR beta gene to the p24 band of chromosome 3". Hum. Genet. 80 (2): 189–90.  
  3. ^ Perlmann T, Jansson L (April 1995). "A novel pathway for vitamin A signaling mediated by RXR heterodimerization with NGFI-B and NURR1". Genes Dev. 9 (7): 769–82.  

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.