Ro01-6128

Ro01-6128

Ro01-6128
Systematic (IUPAC) name
ethyl diphenylacetylcarbamate
Clinical data
Legal status
?
Identifiers
ATC code ?
PubChem
IUPHAR ligand
Chemical data
Formula C17H17NO3 
Mol. mass 283.321 g/mol
 YesY   

Ro01-6128 is a drug used in scientific research, which acts as a selective positive allosteric modulator for the metabotropic glutamate receptor subtype mGluR1.[1][2][3] It was derived by modification of a lead compound found via high-throughput screening, and was further developed to give the improved compound Ro67-4853.[4]

References

  1. ^ Knoflach F, Mutel V, Jolidon S, Kew JN, Malherbe P, Vieira E, Wichmann J, Kemp JA (November 2001). "Positive allosteric modulators of metabotropic glutamate 1 receptor: characterization, mechanism of action, and binding site". Proceedings of the National Academy of Sciences of the United States of America 98 (23): 13402–7.  
  2. ^ Hemstapat K, de Paulis T, Chen Y, Brady AE, Grover VK, Alagille D, Tamagnan GD, Conn PJ (August 2006). "A novel class of positive allosteric modulators of metabotropic glutamate receptor subtype 1 interact with a site distinct from that of negative allosteric modulators". Molecular Pharmacology 70 (2): 616–26.  
  3. ^ Sheffler DJ, Conn PJ (September 2008). "Allosteric potentiators of metabotropic glutamate receptor subtype 1a differentially modulate independent signaling pathways in baby hamster kidney cells". Neuropharmacology 55 (4): 419–27.  
  4. ^ Wichmann J, Bleicher K, Vieira E, Woltering T, Knoflach F, Mutel V (December 2002). "Alkyl diphenylacetyl, 9H-xanthene- and 9H-thioxanthene-carbonyl carbamates as positive allosteric modulators of mGlu1 receptors". Farmaco (Società Chimica Italiana : 1989) 57 (12): 989–92.