Rogletimide

Rogletimide

Rogletimide
Systematic (IUPAC) name
3-ethyl-3-(pyridin-4-yl)piperidine-2,6-dione
Clinical data
Legal status
?
Identifiers
CAS number
ATC code ?
PubChem
ChemSpider
UNII  YesY
Chemical data
Formula C12H14N2O2 
Mol. mass 218.25 g/mol

Rogletimide is a drug related in chemical structure to the sedative glutethimide, but instead having pharmacological activity as a selective aromatase inhibitor similar to the related drug aminoglutethimide, but with no significant sedative effect.[1] This makes it potentially useful in the treatment of some forms of cancer, and with less side effects than aminoglutethimide, but its lower potency caused it to be unsuccessful in clinical trials.[2]

See also

References

  1. ^ Vanden Bossche HV, Moereels H, Koymans LM (1994). "Aromatase inhibitors--mechanisms for non-steroidal inhibitors". Breast Cancer Research and Treatment 30 (1): 43–55.  
  2. ^ MacNeill FA, Jones AL, Jacobs S, Lønning PE, Powles TJ, Dowsett M (October 1992). "The influence of aminoglutethimide and its analogue rogletimide on peripheral aromatisation in breast cancer". British Journal of Cancer 66 (4): 692–7.