SKF-97,541
Systematic (IUPAC) name
3-aminopropyl(methyl)phosphinic acid
Clinical data
Legal status
?
Identifiers
CAS number  YesY
ATC code None
PubChem
Chemical data
Formula C4H12NO2P 
Mol. mass 137.117 g/mol
 YesY   

SKF-97,541 is a compound used in scientific research which acts primarily as a selective GABAB receptor agonist.[1] It has sedative effects in animal studies and is widely used in research into potential treatment of various types of drug addiction.[2][3][4][5][6][7]

References

  1. ^ Seabrook GR, Howson W, Lacey MG (December 1990). "Electrophysiological characterization of potent agonists and antagonists at pre- and postsynaptic GABAB receptors on neurones in rat brain slices".  
  2. ^ Jackson GL, Kuehl D (May 2002). "The GABA(B) antagonist CGP 52432 attenuates the stimulatory effect of the GABA(B) agonist SKF 97541 on luteinizing hormone secretion in the male sheep". Experimental Biology and Medicine (Maywood, N.J.) 227 (5): 315–20.  
  3. ^ Besheer J, Lepoutre V, Hodge CW (July 2004). "GABA(B) receptor agonists reduce operant ethanol self-administration and enhance ethanol sedation in C57BL/6J mice". Psychopharmacology 174 (3): 358–66.  
  4. ^ Carter LP, Chen W, Coop A, Koek W, France CP (May 2006). "Discriminative stimulus effects of GHB and GABA(B) agonists are differentially attenuated by CGP35348". European Journal of Pharmacology 538 (1-3): 85–93.  
  5. ^ Koek W, Mercer SL, Coop A (June 2007). "Cataleptic effects of gamma-hydroxybutyrate (GHB), its precursor gamma-butyrolactone (GBL), and GABAB receptor agonists in mice: differential antagonism by the GABAB receptor antagonist CGP35348". Psychopharmacology 192 (3): 407–14.  
  6. ^ Koek W, Mercer SL, Coop A, France CP (September 2009). "Behavioral effects of gamma-hydroxybutyrate, its precursor gamma-butyrolactone, and GABA(B) receptor agonists: time course and differential antagonism by the GABA(B) receptor antagonist 3-aminopropyl(diethoxymethyl)phosphinic acid (CGP35348)". The Journal of Pharmacology and Experimental Therapeutics 330 (3): 876–83.  
  7. ^ Frankowska M, Nowak E, Filip M (2009). "Effects of GABAB receptor agonists on cocaine hyperlocomotor and sensitizing effects in rats". Pharmacological Reports : PR 61 (6): 1042–9.