SLC22A12

SLC22A12

Solute carrier family 22 (organic anion/urate transporter), member 12
Identifiers
SLC22A12 Gene
Orthologs
SpeciesHumanMouse

Solute carrier family 22 (organic anion/cation transporter), member 12, also known as SLC22A12 and URAT1, is a protein which in humans is encoded by the SLC22A12 gene.[1][2]

Function

The protein encoded by this gene is a urate transporter and urate-anion exchanger which regulates the level of urate in the blood. This protein is an integral membrane protein primarily found in kidney. Two transcript variants encoding different isoforms have been found for this gene.[1]

Clinical significance

Numerous single nucleotide polymorphisms of this gene are significantly associated with altered (increased or decreased) reabsorption of uric acid by the kidneys.[3][4] Respectively, these altered rates of reabsorption contribute to hyperuricemia and hypouricemia.

See also

Interactions

SLC22A12 has been shown to interact with PDZK1.[5]

References

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.