Solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2
PDB rendering based on 2dh2.
Available structures
PDB Ortholog search: RCSB
SLC3A2 Gene
RNA expression pattern

4F2 cell-surface antigen heavy chain is a protein that in humans is encoded by the SLC3A2 (solute carrier family 3 member 2) gene.[1][2]

SLC3A2 comprises the light subunit of the large neutral amino acid transporter (LAT1) that is also known as CD98 (cluster of differentiation 98).[3][4]


SLC3A2 is a member of the solute carrier family and encodes a cell surface, transmembrane protein with an alpha-amylase domain. The protein exists as the heavy chain of a heterodimer, covalently bound through di-sulfide bonds to one of several possible light chains. It associates with integrins and mediates integrin-dependent signaling related to normal cell growth and tumorigenesis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.[2]

LAT1 is a heterodimeric membrane transport protein that preferentially transports neutral branched (valine, leucine, isoleucine) and aromatic (tryptophan, tyrosine) amino acids.[5] LAT is highly expressed in brain capillaries (which form the blood brain barrier) relative to other tissues.[5]

A functional LAT1 transporter is composed of two proteins encoded by two distinct genes:

  • 4F2hc/CD98 heavy subunit protein encoded by the SLC3A2 gene (this gene)[6]
  • CD98 light subunit protein encoded by the SLC7A5 gene[7]


SLC3A2 has been shown to interact with SLC7A7.[8]

See also

  • Heterodimeric amino acid transporter


Further reading

External links

  • Medical Subject Headings (MeSH)
  • Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.