STAT1

STAT1

Signal transducer and activator of transcription 1, 91kDa

STAT1 bound to DNA
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols  ; CANDF7; ISGF-3; STAT91
External IDs ChEMBL: GeneCards:
RNA expression pattern
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)
RefSeq (protein)
Location (UCSC)
PubMed search

STAT1 is a member of the Signal Transducers and Activators of Transcription family of transcription factors. STAT1 is involved in upregulating genes due to a signal by either type I, type II, or type III interferons. In response to IFN-γ stimulation, STAT1 forms homodimers or heterodimers with STAT3 that bind to the GAS (Interferon-Gamma-Activated Sequence) promoter element; in response to either IFN-α or IFN-β stimulation, STAT1 forms a heterodimer with STAT2 that can bind the ISRE (Interferon-Stimulated Response Element) promoter element.[1] In either case, binding of the promoter element leads to an increased expression of ISG (Interferon-Stimulated Genes).

Expression of STAT1 can be induced with diallyl disulfide, a compound in garlic.[2]

Interactions

STAT1 has been shown to interact with Protein kinase R,[3][4] Src,[5][6] IRF1,[7] STAT3,[8][9][10] MCM5,[11][12] STAT2,[13][14][15] CD117,[16] Fanconi anemia, complementation group C,[17][18][19] CREB-binding protein,[20] Interleukin 27 receptor, alpha subunit,[21] PIAS1,[22] BRCA1,[23] Epidermal growth factor receptor,[5][10] PTK2,[24] Mammalian target of rapamycin,[25] IFNAR2,[26][27] PRKCD,[25] TRADD,[28] C-jun,[29] Calcitriol receptor,[30] ISGF3G[31] and GNB2L1.[27][32]

References

  1. ^ Michael G. Katze, Yupeng He & Michael Gale et al. (2002). "Viruses and interferon: a fight for supremacy". Nature Reviews Immunology 2 (9): 675–87.  
  2. ^ Lu HF, Yang JS, Lin YT, Tan TW, Ip SW, Li YC, Tsou MF, Chung JG. (2007). "Diallyl disulfide induced signal transducer and activator of transcription 1 expression in human colon cancer colo 205 cells using differential display RT-PCR". Cancer Genomics Proteomics. 4 (2): 93–7.  
  3. ^ Wong, A H; Tam N W; Yang Y L; Cuddihy A R; Li S; Kirchhoff S; Hauser H; Decker T; Koromilas A E (March 1997). "Physical association between STAT1 and the interferon-inducible protein kinase PKR and implications for interferon and double-stranded RNA signaling pathways". EMBO J. (ENGLAND) 16 (6): 1291–304.  
  4. ^ Wong, A H; Durbin J E; Li S; Dever T E; Decker T; Koromilas A E (April 2001). "Enhanced antiviral and antiproliferative properties of a STAT1 mutant unable to interact with the protein kinase PKR". J. Biol. Chem. (United States) 276 (17): 13727–37.  
  5. ^ a b Olayioye, M A; Beuvink I; Horsch K; Daly J M; Hynes N E (June 1999). "ErbB receptor-induced activation of stat transcription factors is mediated by Src tyrosine kinases". J. Biol. Chem. (United States) 274 (24): 17209–18.  
  6. ^ Cirri, P; Chiarugi P; Marra F; Raugei G; Camici G; Manao G; Ramponi G (October 1997). "c-Src activates both STAT1 and STAT3 in PDGF-stimulated NIH3T3 cells". Biochem. Biophys. Res. Commun. (United States) 239 (2): 493–7.  
  7. ^ Chatterjee-Kishore, M; van Den Akker F; Stark G R (July 2000). "Adenovirus E1A down-regulates LMP2 transcription by interfering with the binding of stat1 to IRF1". J. Biol. Chem. (United States) 275 (27): 20406–11.  
  8. ^ Gunaje, J J; Bhat G J (October 2001). "Involvement of tyrosine phosphatase PTP1D in the inhibition of interleukin-6-induced Stat3 signaling by alpha-thrombin". Biochem. Biophys. Res. Commun. (United States) 288 (1): 252–7.  
  9. ^ Spiekermann, K; Biethahn S; Wilde S; Hiddemann W; Alves F (August 2001). "Constitutive activation of STAT transcription factors in acute myelogenous leukemia". Eur. J. Haematol. (Denmark) 67 (2): 63–71.  
  10. ^ a b Xia, Ling; Wang Lijuan; Chung Alicia S; Ivanov Stanimir S; Ling Mike Y; Dragoi Ana M; Platt Adam; Gilmer Tona M; Fu Xin-Yuan; Chin Y Eugene (August 2002). "Identification of both positive and negative domains within the epidermal growth factor receptor COOH-terminal region for signal transducer and activator of transcription (STAT) activation". J. Biol. Chem. (United States) 277 (34): 30716–23.  
  11. ^ Zhang, J J; Zhao Y; Chait B T; Lathem W W; Ritzi M; Knippers R; Darnell J E (Dec 1998). "Ser727-dependent recruitment of MCM5 by Stat1alpha in IFN-gamma-induced transcriptional activation". EMBO J. (ENGLAND) 17 (23): 6963–71.  
  12. ^ DaFonseca, C J; Shu F; Zhang J J (March 2001). "Identification of two residues in MCM5 critical for the assembly of MCM complexes and Stat1-mediated transcription activation in response to IFN-gamma".  
  13. ^ Li, X; Leung S; Qureshi S; Darnell J E; Stark G R (March 1996). "Formation of STAT1-STAT2 heterodimers and their role in the activation of IRF-1 gene transcription by interferon-alpha". J. Biol. Chem. (United States) 271 (10): 5790–4.  
  14. ^ Dumler, I; Kopmann A; Wagner K; Mayboroda O A; Jerke U; Dietz R; Haller H; Gulba D C (August 1999). "Urokinase induces activation and formation of Stat4 and Stat1-Stat2 complexes in human vascular smooth muscle cells". J. Biol. Chem. (United States) 274 (34): 24059–65.  
  15. ^ Fagerlund, Riku; Mélen Krister; Kinnunen Leena; Julkunen Ilkka (August 2002). "Arginine/lysine-rich nuclear localization signals mediate interactions between dimeric STATs and importin alpha 5". J. Biol. Chem. (United States) 277 (33): 30072–8.  
  16. ^ Deberry, C; Mou S; Linnekin D (October 1997). "Stat1 associates with c-kit and is activated in response to stem cell factor". Biochem. J. (ENGLAND) 327 (1): 73–80.  
  17. ^ Pang, Q; Fagerlie S; Christianson T A; Keeble W; Faulkner G; Diaz J; Rathbun R K; Bagby G C (July 2000). "The Fanconi anemia protein FANCC binds to and facilitates the activation of STAT1 by gamma interferon and hematopoietic growth factors". Mol. Cell. Biol. (United States) 20 (13): 4724–35.  
  18. ^ Reuter, Tanja Y; Medhurst Annette L, Waisfisz Quinten, Zhi Yu, Herterich Sabine, Hoehn Holger, Gross Hans J, Joenje Hans, Hoatlin Maureen E, Mathew Christopher G, Huber Pia A J (October 2003). "Yeast two-hybrid screens imply involvement of Fanconi anemia proteins in transcription regulation, cell signaling, oxidative metabolism, and cellular transport". Exp. Cell Res. (United States) 289 (2): 211–21.  
  19. ^ Pang, Q; Christianson T A; Keeble W; Diaz J; Faulkner G R; Reifsteck C; Olson S; Bagby G C (September 2001). "The Fanconi anemia complementation group C gene product: structural evidence of multifunctionality". Blood (United States) 98 (5): 1392–401.  
  20. ^ Zhang, J J; Vinkemeier U; Gu W; Chakravarti D; Horvath C M; Darnell J E (Dec 1996). "Two contact regions between Stat1 and CBP/p300 in interferon gamma signaling".  
  21. ^ Takeda, Atsunobu; Hamano Shinjiro; Yamanaka Atsushi; Hanada Toshikatsu; Ishibashi Tatsuro; Mak Tak W; Yoshimura Akihiko; Yoshida Hiroki (May 2003). "Cutting edge: role of IL-27/WSX-1 signaling for induction of T-bet through activation of STAT1 during initial Th1 commitment". J. Immunol. (United States) 170 (10): 4886–90.  
  22. ^ Liao, J; Fu Y; Shuai K (May 2000). "Distinct roles of the NH2- and COOH-terminal domains of the protein inhibitor of activated signal transducer and activator of transcription (STAT) 1 (PIAS1) in cytokine-induced PIAS1-Stat1 interaction".  
  23. ^ Ouchi, T; Lee S W; Ouchi M; Aaronson S A; Horvath C M (May 2000). "Collaboration of signal transducer and activator of transcription 1 (STAT1) and BRCA1 in differential regulation of IFN-gamma target genes".  
  24. ^ Xie, B; Zhao J; Kitagawa M; Durbin J; Madri J A; Guan J L; Fu X Y (June 2001). "Focal adhesion kinase activates Stat1 in integrin-mediated cell migration and adhesion". J. Biol. Chem. (United States) 276 (22): 19512–23.  
  25. ^ a b Kristof, Arnold S; Marks-Konczalik Joanna, Billings Eric, Moss Joel (September 2003). "Stimulation of signal transducer and activator of transcription-1 (STAT1)-dependent gene transcription by lipopolysaccharide and interferon-gamma is regulated by mammalian target of rapamycin". J. Biol. Chem. (United States) 278 (36): 33637–44.  
  26. ^ Li, X; Leung S; Kerr I M; Stark G R (April 1997). "Functional subdomains of STAT2 required for preassociation with the alpha interferon receptor and for signaling". Mol. Cell. Biol. (United States) 17 (4): 2048–56.  
  27. ^ a b Usacheva, A; Smith R; Minshall R; Baida G; Seng S; Croze E; Colamonici O (June 2001). "The WD motif-containing protein receptor for activated protein kinase C (RACK1) is required for recruitment and activation of signal transducer and activator of transcription 1 through the type I interferon receptor". J. Biol. Chem. (United States) 276 (25): 22948–53.  
  28. ^ Wang, Y; Wu T R; Cai S; Welte T; Chin Y E (July 2000). "Stat1 as a component of tumor necrosis factor alpha receptor 1-TRADD signaling complex to inhibit NF-kappaB activation". Mol. Cell. Biol. (United States) 20 (13): 4505–12.  
  29. ^ Zhang, X; Wrzeszczynska M H; Horvath C M; Darnell J E (October 1999). "Interacting regions in Stat3 and c-Jun that participate in cooperative transcriptional activation". Mol. Cell. Biol. (United States) 19 (10): 7138–46.  
  30. ^ Vidal, Marcos; Ramana Chilakamarti V; Dusso Adriana S (April 2002). "Stat1-vitamin D receptor interactions antagonize 1,25-dihydroxyvitamin D transcriptional activity and enhance stat1-mediated transcription". Mol. Cell. Biol. (United States) 22 (8): 2777–87.  
  31. ^ Horvath, C M; Stark G R; Kerr I M; Darnell J E (Dec 1996). "Interactions between STAT and non-STAT proteins in the interferon-stimulated gene factor 3 transcription complex". Mol. Cell. Biol. (United States) 16 (12): 6957–64.  
  32. ^ Usacheva, Anna; Tian Xinyong; Sandoval Raudel; Salvi Debra; Levy David; Colamonici Oscar R (September 2003). "The WD motif-containing protein RACK-1 functions as a scaffold protein within the type I IFN receptor-signaling complex". J. Immunol. (United States) 171 (6): 2989–94.  

Further reading

External links

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