Schizotypal personality disorder

Schizotypal personality disorder

Schizotypal disorder
Classification and external resources
ICD-10 F21
ICD-9-CM 301.22
MedlinePlus 001525
MeSH D012569

Schizotypal personality disorder (STPD) is a personality disorder characterized by a need for social isolation, anxiety in social situations, odd behavior and thinking, and often unconventional beliefs. People with this disorder feel extreme discomfort with maintaining close relationships with people, so they avoid forming them. Peculiar speech mannerisms and odd modes of dress are also diagnostic signs of this disorder. In some cases, people with STPD may react oddly in conversations, not respond, or talk to themselves.[1] They frequently misinterpret situations as being strange or having unusual meaning for them; paranormal and superstitious beliefs are not uncommon. Such people frequently seek medical attention for anxiety or depression instead of their personality disorder.[2] Schizotypal personality disorder occurs in approximately 3% of the general population and is slightly more common in males.[3]

The term "schizotypal" is derived from "schizotype," and was coined by Sandor Rado in 1956 as an abbreviation of one phenotype of a "schizophrenic genotype".[4] In a small proportion of cases, schizotypal personality disorder may be a precursor to schizophrenia, but normally has a relatively stable course.[5]


  • Causes 1
    • Genetic 1.1
    • Social and environmental 1.2
  • Comorbidity 2
    • Axis I 2.1
    • Axis II 2.2
  • Diagnosis 3
    • DSM-5 3.1
    • ICD 3.2
      • Diagnostic guidelines 3.2.1
      • Includes 3.2.2
      • Excludes 3.2.3
    • Subtypes 3.3
    • Differential diagnosis 3.4
  • Treatment 4
    • Pharmacological treatment 4.1
    • Psychotherapy 4.2
  • Epidemiology 5
  • See also 6
  • References 7
  • External links 8



Although listed in the DSM-IV-TR on axis II, schizotypal personality disorder is widely understood to be a "schizophrenia spectrum" disorder that is on axis I. Rates of schizotypal personality disorder are much higher in relatives of individuals with schizophrenia than in the relatives of people with other mental illnesses or in people without mentally ill relatives. Technically speaking, schizotypal personality disorder may also be considered an "extended phenotype" that helps geneticists track the familial or genetic transmission of the genes that are implicated in schizophrenia.[6]

Social and environmental

There is now evidence to suggest that parenting styles, early separation, trauma/maltreatment history (especially early childhood neglect) can lead to the development of schizotypal traits.[7][8]

Over time, children learn to interpret social cues and respond appropriately but for unknown reasons this process does not work well for people with this disorder.[9] Neglect or abuse, trauma, or family dysfunction during childhood can increase the risk of developing schizotypal personality disorder.[10]

Schizotypal personality disorders are characterized by a common attentional impairment in various degrees.[11] A study suggested that attention deficits could serve as a marker of biological susceptibility to schizotypal personality disorder.[11] The reason is that an individual who has difficulties taking in information may find it difficult in complicated social situations where interpersonal cues and attentive communications are essential for quality interaction. This might eventually cause the individual to withdraw from most social interactions, thus leading to asociality.[11]


Axis I

Schizotypal personality disorder usually co-occurs with major depressive disorder, dysthymia, and generalized social phobia.[12] Furthermore, sometimes schizotypal personality disorder can co-occur with obsessive-compulsive disorder, and its presence appears to affect treatment outcome adversely.[13]

Some persons with schizotypal personality disorders go on to develop schizophrenia,[14] but most of them do not.[15] Although STPD symptomatology has been studied longitudinally in a number of community samples, the results received do not suggest any significant likelihood of the development of schizophrenia.[16] There are dozens of studies showing that individuals with schizotypal personality disorder score similar to individuals with schizophrenia on a very wide range of neuropsychological tests. Cognitive deficits in patients with schizotypal personality disorder are very similar to, but quantitatively milder than, those for patients with schizophrenia.[17] A 2004 study, however, reported neurological evidence that did "not entirely support the model that SPD is simply an attenuated form of schizophrenia".[18]

In case of methamphetamine use, persons with schizotypal personality disorders are at great risk of developing permanent psychosis.[19]

Axis II

In most instances, schizotypal personality disorders co-occurs with the schizoid, paranoid, avoidant, and borderline personality disorders.[20]



In the American Psychiatric Association's DSM-5, schizotypal personality disorder is defined as a "pervasive pattern of social and interpersonal deficits marked by acute discomfort with, and reduced capacity for, close relationships as well as by cognitive or perceptual distortions and eccentricities of behavior, beginning by early adulthood and present in a variety of contexts." At least five of the following symptoms must be present: ideas of reference, strange beliefs or magical thinking, abnormal perceptual experiences, strange thinking and speech, paranoia, inappropriate or constricted affect, strange behavior or appearance, lack of close friends, and excessive social anxiety that does not abate and stems from paranoia rather than negative judgments about self. These symptoms must not occur only during the course of disorder with similar symptoms (e.g., schizophrenia or autism spectrum disorder).[5]


The ICD-10 uses the name schizotypal disorder (F21). It is classified as a clinical disorder associated with schizophrenia, rather than a personality disorder as in DSM-5.[21] The DSM-IV designation of schizotypal as a personality disorder is controversial.

The ICD definition is:

A disorder characterized by eccentric behavior and anomalies of thinking and affect which resemble those seen in schizophrenia, though no definite and characteristic schizophrenic anomalies have occurred at any stage. There is no dominant or typical disturbance, but any of the following may be present:
  • Inappropriate or constricted affect (the individual appears cold and aloof);
  • Behavior or appearance that is odd, eccentric or peculiar;
  • Poor rapport with others and a tendency to withdraw socially;
  • Odd beliefs or magical thinking, influencing behavior and inconsistent with subcultural norms;
  • Suspiciousness or paranoid ideas;
  • Obsessive ruminations without inner resistance, often with dysmorphophobic, sexual or aggressive contents;
  • Unusual perceptual experiences including somatosensory (bodily) or other illusions, depersonalization or derealization;
  • Vague, circumstantial, metaphorical, over-elaborate or stereotyped thinking, manifested by odd speech or in other ways, without gross incoherence;
  • Occasional transient quasi-psychotic episodes with intense illusions, auditory or other hallucinations and delusion-like ideas, usually occurring without external provocation.
The disorder runs a chronic course with fluctuations of intensity. Occasionally it evolves into overt schizophrenia. There is no definite onset and its evolution and course are usually those of a personality disorder. It is more common in individuals related to people with schizophrenia and is believed to be part of the genetic "spectrum" of schizophrenia.

Diagnostic guidelines

This diagnostic rubric is not recommended for general use because it is not clearly demarcated either from simple schizophrenia or from schizoid or paranoid personality disorders, or possibly autism and aspergers as currently diagnosed. If the term is used, three or four of the typical features listed above should have been present, continuously or episodically, for at least 2 years. The individual must never have met criteria for schizophrenia itself. A history of schizophrenia in a first-degree relative gives additional weight to the diagnosis but is not a prerequisite.




Theodore Millon proposes two subtypes of schizotypal.[4][22] Any individual with schizotypal personality disorder may exhibit either one of the following somewhat different subtypes (Note that Millon believes it is rare for a personality with one pure variant, but rather a mixture of one major variant with one or more secondary variants):

Subtype Description Personality Traits
Insipid schizotypal A structural exaggeration of the passive-detached pattern. It includes schizoid, depressive, dependent features. Sense of strangeness and nonbeing; overtly drab, sluggish, inexpressive; internally bland, barren, indifferent, and insensitive; obscured, vague, and tangential thoughts.
Timorous schizotypal A structural exaggeration of the active-detached pattern. It includes avoidant, negativistic (passive-aggressive) features. Warily apprehensive, watchful, suspicious, guarded, shrinking, deadens excess sensitivity; alienated from self and others; intentionally blocks, reverses, or disqualifies own thoughts.

Differential diagnosis

There is a high rate of comorbidity with other personality disorders. McGlashan et al. (2000) stated that this may be due to overlapping criteria with other personality disorders, such as avoidant personality disorder, paranoid personality disorder and borderline personality disorder.[23]

There are many similarities between the schizotypal and schizoid personalities. Most notable of the similarities is the inability to initiate or maintain relationships (both friendly and romantic). The difference between the two seems to be that those labeled as schizotypal avoid social interaction because of a deep-seated fear of people. The schizoid individuals simply feel no desire to form relationships, because they see no point in sharing their time with others.


Pharmacological treatment

STPD is rarely seen as the primary reason for treatment in a clinical setting, but it occurs often as a comorbid finding with other mental disorders. When patients with STPD are prescribed pharmaceuticals, they are most often prescribed the same drugs used to treat patients suffering from schizophrenia including traditional neuroleptics such as haloperidol and thiothixene.[24] In order to decide which type of medication should be used, Paul Markovitz distinguishes two basic groups of schizotypal patients:[25]

  • Schizotypal patients who appear to be almost schizophrenic in their beliefs and behaviors (aberrant perceptions and cognitions) - they are usually treated with low doses of antipsychotic medications, e.g. thiothixene. However, it must be mentioned that long-term efficacy of neuroleptics is doubtful.
  • Schizotypal patients who are more obsessive-compulsive in their beliefs and behaviors - in this case SSRIs, e.g. Sertraline, appear to be more effective.
  • Lamotrigine an anti-convulsant, appears to be helpful in dealing with social isolation.


According to Theodore Millon, the schizotypal is one of the easiest personality disorders to identify but one of the most difficult to treat with psychotherapy.[4] Persons with STPD usually consider themselves to be simply eccentric, creative, or nonconformist. As a rule, they underestimate maladaptiveness of their social isolation and perceptual distortions. It is not so easy to develop rapport with people who suffer from STPD due to the fact that increasing familiarity and intimacy usually increase their level of anxiety and discomfort. In most cases they do not respond to informality and humor.[26]

Group therapy is recommended for persons with STPD only if the group is well structured and supportive. Otherwise it could lead to loose and tangential ideation.[25] Support is especially important for schizotypal patients with predominant paranoid symptoms, because they will have a lot of difficulties even in highly structured groups.[4]


Reported prevalence of STPD in community studies ranges from 0.6% in a Norwegian sample, to 4.6% in an American sample.[5] A large American study found a lifetime prevalence of 3.9%, with somewhat higher rates among men (4.2%) than women (3.7%).[3] It is uncommon in clinical populations, with reported rates of 0% to 1.9%.[5]

A University of Colorado Colorado Springs study comparing personality disorders and Myers-Briggs Type Indicator types found that the disorder had a significant correlation with the Introverted (I), Intuitive (N), Thinking (T), and Perceiving (P) preferences.[27]

See also


  1. ^ Schacter, Daniel L., Daniel T. Gilbert, and Daniel M. Wegner. Psychology. Worth Publishers, 2010. Print.
  2. ^ American Psychiatric Association (2013). Diagnostic and Statistical Manual of Mental Disorders (Fifth ed.). Arlington, VA: American Psychiatric Publishing. p. 657.  
  3. ^ a b Pulay, A. J., Stinson, F. S., Dawson, D. A., Goldstein, R. B., Chou, S. P., Huang, B.; et al. (2009). "Prevalence, correlates, disability, and comorbidity of DSM-IV schizotypal personality disorder: results from the wave 2 national epidemiologic survey on alcohol and related conditions". Primary Care Companion to the Journal of Clinical Psychiatry 11 (2): 53–67.  
  4. ^ a b c d Millon, Theodore (2004). Personality Disorders in Modern Life. John Wiley & Sons, Inc., Hoboken, New Jersey. ISBN 0-471-23734-5.
  5. ^ a b c d American Psychiatric Association, ed. (2013). "Schizotypal Personality Disorder, 301.22 (F21)". Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition. American Psychiatric Publishing. p. 655-659. 
  6. ^ Fogelson, D.L., Nuechterlein, K.H., Asarnow, R.F., et al., (2007). Avoidant personality disorder is a separable schizophrenia-spectrum personality disorder even when controlling for the presence of paranoid and schizotypal personality disorders: The UCLA family study. Schizophrenia Research, 91, 192-199.
  7. ^ Deidre M. Anglina, Patricia R. Cohenab, Henian Chena (2008) Duration of early maternal separation and prediction of schizotypal symptoms from early adolescence to midlife, Schizophrenia Research Volume 103, Issue 1, Pages 143-150 (August 2008)
  8. ^ Howard Berenbaum, Ph.D., Eve M. Valera, Ph.D. and John G. Kerns, Ph.D. (2003) Psychological Trauma and Schizotypal Symptoms, Oxford Journals, Medicine, Schizophrenia Bulletin Volume 29, Number 1 Pp. 143-152
  9. ^ Mayo Clinic Staff. "Schizotypal personality disorder". Mayo Clinic. Retrieved 21 February 2012. 
  10. ^ Mayo Clinic Staff. "Schizotypal personality disorder Risk factors". Mayo Clinic. Retrieved 21 February 2012. 
  11. ^ a b c Roitman,S.E.L et al. Attentional Functioning in Schizotypal Personality Disorder, 1997
  12. ^ Adams, Henry E., Sutker, Patricia B. (2001). Comprehensive Handbook of Psychopathology. Third Edition. Springer. ISBN 978-0306464904.
  13. ^ Murray, Robin M. et al (2008). Psychiatry. Fourth Edition. Cambridge University Press. ISBN 978-0-521-60408-6.
  14. ^ Walker, E., Kestler, L., Bollini, A.; et al. (2004). "Schizophrenia: etiology and course". Annual Review of Psychology 55: 401–430.  
  15. ^ Raine, A. (2006). "Schizotypal personality: Neurodevelopmental and psychosocial trajectories". Annual Review of Psychology 2: 291–326.  
  16. ^ Gooding DC, Tallent KA, Matts CW (2005). "Clinical status of at-risk individuals 5 years later: Further validation of the psychometric high-risk strategy". Journal of Abnormal Psychology 114: 170–175.  
  17. ^ Matsui, M., Sumiyoshi, T., Kato, K., et al., (2004). Neuropsychological profile in patients with schizotypal personality disorder or schizophrenia. Psychological Reports, 94(2), 387-397.
  18. ^ Haznedar, M. M.; Buchsbaum, M. S.; Hazlett, E. A.; Shihabuddin, L.; New, A.; Siever, L. J. (2004). "Cingulate gyrus volume and metabolism in the schizophrenia spectrum". Schizophrenia Research 71 (2–3): 249–262.  
  19. ^ Chen, C. K., Lin, S. K., Sham, P. C.; et al. (2005). "Morbid risk for psychiatric disorder among the relatives of methamphetamine users with and without psychosis". American Journal of Medical Genetics 136: 87–91.  
  20. ^ Tasman, Allan et al (2008). Psychiatry. Third Edition. John Wiley & Sons, Ltd. ISBN 978-0470-06571-6.
  21. ^ Schizotypal personality disorder -International Statistical Classification of Diseases and Related Health Problems 10th Revision (ICD-10)
  22. ^ Millon, Theodore - Personality Subtypes
  23. ^ McGlashan, T.H., Grilo, C.M., Skodol, A.E., Gunderson, J.G., Shea, M.T., Morey, L.C., et al. (2000). The collaborative longitudinal personality disorders study: Baseline axis I/II and II/II diagnostic co-occurrence. Acta Psychiatrica Scandinavica, 102, 256-264.
  24. ^ Hoeksema, Susan N. (2014). (ab)normal Psychology. 2 Penn Plaza, New York, NY 10121: McGraw-Hill Education. p. 261.  
  25. ^ a b Livesley, John W. (2001). Handbook of Personality Disorders: Theory, Research, and Treatment. The Guilford Press. ISBN 978-1572306295.
  26. ^ Siever, L.J. (1992). "Schizophrenia spectrum disorders". Review of Psychiatry 11: 25–42. 
  27. ^ "An Empirical Investigation of Jung's Personality Types and Psychological Disorder Features" (PDF). Journal of Psychological Type/ 

External links

  • ICD-10 diagnostic criteria for Schizotypal Disorder
  • Link collection for resources on Schizotypal Disorder
  • Video lecture by Stanford professor Robert Sapolsky on schizotypal personality and "metamagical thinking"