Serotonin antagonist

Serotonin antagonist

A serotonin antagonist is a drug used to inhibit the action at serotonin (5-HT) receptors.


5-HT2A antagonists

Antagonists of the 5-HT2A receptor are sometimes used as atypical antipsychotics (contrast with typical antipsychotics, which are purely dopamine antagonists). They include:

5-HT2A/2C antagonists

5-HT3 antagonists

Another subclass consists of drugs selectively acting at the 5-HT3 receptors, and thus are known as 5-HT3 antagonists. They are efficacious in treating chemotherapy-induced emesis and postoperative nausea and vomiting.[1] They include:

Other 5-HT3 antagonists are used for the treatment of irritable bowel syndrome:

Non-selective 5-HT antagonists

Please note, that although some non-selective serotonin antagonists may have an particular affinity for a specific 5-HT receptor (and thus may be listed above eg methysergide), they still may also possess a generalised non-selective action.

Serotonin anatagonists acting as antihistamines for allergic conditions


  • Feverfew Is a herb traditionally used for migraines.
  • Fenclonine An inhibitor of serotonin synthesis that has been used in the treatment of carcinoid syndrome.
  • Reserpine Depletes serotonin stores in the brain, heart, and many other organs and has been used in hypertension and psychoses

See also


  1. ^ Lindley, C.; Blower, P. (2000). "Oral serotonin type 3-receptor antagonists for prevention of chemotherapy-induced emesis". American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 57 (18): 1685–1697.  

External links