Diagram showing the small intestine and surrounding structures
|Superior mesenteric artery|
|Hepatic portal vein|
|Celiac ganglia, vagus|
|Intestinal lymph trunk|
The small intestine or small bowel is the part of the gastrointestinal tract between the stomach and the large intestine, and is where much of the digestion and absorption of food takes place. The small intestine has three distinct regions – the duodenum, jejunum, and ileum. It receives bile and pancreatic juice through the pancreatic duct, controlled by the sphincter of Oddi. The primary function of the small intestine is the absorption of nutrients and minerals from food.
This article is primarily about the human gastrointestinal tract. The information about its processes is directly applicable to most placental mammals. A major exception to this is the digestive process in ruminants – notably cows. In invertebrates such as worms, the term "large intestine" is often used to describe the entire gastrointestinal tract.
- Histology 1.1
- Development 1.2
- Digestion 2.1
- Absorption 2.2
- Immunological 2.3
- Clinical significance 3
- Other animals 4
- Society and culture 5
- Additional images 6
- See also 7
- Notes and references 8
- Bibliography 9
The average length of the small intestine in an adult human male is 6.9 m (22 ft 8 in), and 7.1 m (23 ft 4 in) in an adult female. It can vary greatly, from as short as 4.6 m (15 ft) to as long as 9.8 m (32 ft). Recent studies indicate that small intestine may be shorter, around 3.5 m (11 ft 6 in), and that the length is less affected by age after childhood than expected
It is approximately 2.5–3 cm in diameter. The surface area of the human small intestinal mucosa averages 30 square meters. 
The small intestine is divided into three structural parts. The duodenum is a short structure (about 20–25 cm long) continuous with the stomach and shaped like a "C". It surrounds the head of the pancreas. It receives gastric chyme from the stomach, together with digestive juices from the pancreas (digestive enzymes) and the gall bladder (bile). The digestive enzymes break down proteins and bile and emulsify fats into micelles. The duodenum contains Brunner's glands, which produce a mucus-rich alkaline secretion containing bicarbonate. These secretions, in combination with bicarbonate from the pancreas, neutralizes the stomach acids contained in gastric chyme.
The jejunum is the midsection of the small intestine, connecting the duodenum to the ileum. It is about 2.5 m long, and contains the plicae circulares, and villi that increase its surface area. Products of digestion (sugars, amino acids, and fatty acids) are absorbed into the bloodstream here. The suspensory muscle of duodenum marks the division between the duodenum and the jejunum.
The ileum: The final section of the small intestine. It is about 3 m long, and contains villi similar to the jejunum. It absorbs mainly vitamin B12 and bile acids, as well as any other remaining nutrients. The ileum joins to the cecum of the large intestine at the ileocecal junction.
The small intestine receives a blood supply from the
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- Physiology: 6/6ch2/s6ch2_30 - Essentials of Human Physiology
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- Gondolesi, G.; Ramisch, D.; Padin, J.; Almau, H.; Sandi, M.; Schelotto, P.B.; Fernandez, A.; Rumbo, C.; Solar, H. (15 Jun 2012). "What Is the Normal Small Bowel Length in Humans? First Donor-Based Cohort Analysis". American Journal of Transplantation (Arlington, VA: American Society of Transplantation and the American Society of Transplant Surgeons) 12: S49-S54. English: }
- Helander, Herbert F; Fändriks, Lars (2015). "Surface area of the digestive tract – revisited". Scandinavian Journal of Gastroenterology 49 (6): 681–689.
- Drake, Richard L.; Vogl, Wayne; Tibbitts, Adam W.M. Mitchell; illustrations by Richard; Richardson, Paul (2005). Gray's anatomy for students. Philadelphia: Elsevier/Churchill Livingstone. p. 273.
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- Canny, G. O.; McCormick, B. A. (2008). "Bacteria in the Intestine, Helpful Residents or Enemies from Within?". Infection and Immunity 76 (8): 3360–3373.
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Notes and references
Small intestine in situ, greater omentum folded upwards.
Third state of the development of the intestinal canal and peritoneum, seen from in front (diagrammatic). The mode of preparation is the same as in Fig 400
Society and culture
In lampreys, the spiral valve is extremely small, possibly because their diet requires little digestion. Hagfish have no spiral valve at all, with digestion occurring for almost the entire length of the intestine, which is not subdivided into different regions.
There is no small intestine as such in non-teleost fish, such as sharks, sturgeons, and lungfish. Instead, the digestive part of the gut forms a spiral intestine, connecting the stomach to the rectum. In this type of gut, the intestine itself is relatively straight, but has a long fold running along the inner surface in a spiral fashion, sometimes for dozens of turns. This valve greatly increases both the surface area and the effective length of the intestine. The lining of the spiral intestine is similar to that of the small intestine in teleosts and non-mammalian tetrapods.
The boundaries between the duodenum, jejunum, and ileum are somewhat vague even in humans, and such distinctions are either ignored when discussing the anatomy of other animals, or are essentially arbitrary.
In tetrapods, the ileocaecal valve is always present, opening into the colon. The length of the small intestine is typically longer in tetrapods than in teleosts, but is especially so in herbivores, as well as in mammals and birds, which have a higher metabolic rate than amphibians or reptiles. The lining of the small intestine includes microscopic folds to increase its surface area in all vertebrates, but only in mammals do these develop into true villi.
The small intestine is found in all rectum being marked only by the end of the digestive epitheliu 
- Small intestine obstruction or obstructive disorders
- Tropical sprue
- Tape worm (Diphyllobothrium latum, Taenia solium, Hymenolepsis nana)
- Hookworm (e.g. Necator americanus, Ancylostoma duodenale)
- Nematodes (e.g. Ascaris lumbricoides)
- Other Protozoa (e.g. Cryptosporidium parvum, Cyclospora, Microsporidia, Entamoeba histolytica)
- Enterotoxigenic E. coli
- Salmonella enterica
- Clostridium difficile (antibiotic-associated colitis, Pseudomembranous Colitis
- Mycobacterium (disseminated Mycobacterium tuberculosis)
- Whipple's Disease
- Vibrio (Cholera)
- Enteric (Typhoid) Fever (Salmonella enterica var. typhii) and Paratyphoid fever
- Bacillus cereus
- Clostridium perfringens (Gas Gangrene)
- Viral Infections
- Neoplasms (Cancers)
Developmental, Congenital or Genetic Conditions
- Duodenal (Intestinal) Atresia
- Hirschsprung's Disease
- Meckel's Diverticulum
- Pyloric Stenosis
- Pancreas Divisum
- Ectopic Pancreas
- Enteric duplication cyst
- Situs Inversus
- Cystic Fibrosis
- Persistent Urachus
- Disaccharidase (lactase) deficiencies
- Primary Bile Acid Malsorption
- Gardner Syndrome
- Familial Adenomatous Polyposis Syndrome (FAP)
- Crohn's disease, and the more general Inflammatory Bowel Disease
- Typhlitis (neutropenic colitis in the immunosuppressed
- Coeliac disease (Sprue or Non-Tropical Sprue)
- Mesenteric ischemia
- Embolus or Thrombus of the Superior mesenteric artery or the Superior mesenteric vein
- Arteriovenous malformation
- Gastric dumping syndrome
- Irritable Bowel Syndrome
- Duodenal (Peptic) Ulcers
- Gastrointestinal perforation
- Lymphatic Obstruction due to various causes
- Diabetic Neuropathy
- Radiation Enterocolitis
- Drug Induced Injury
- Diversion Colitis
- Mesenteric cysts
- Peritoneal Infection
- Sclerosing Retroperitonitis
- Small intestinal bacterial overgrowth
The small intestine is a complex organ, and as such, there are a very large number of possible conditions that may affect the function of the small bowel. A few of them are listed below, some of which are common, with up to 10% of people being affected at some time in their lives, while others are vanishingly rare.
- Iron is absorbed in the duodenum.
- Vitamin B12 and bile salts are absorbed in the terminal ileum.
- Water and lipids are absorbed by passive diffusion throughout the small intestine.
- Sodium bicarbonate is absorbed by active transport and glucose and amino acid co-transport.
- Fructose is absorbed by facilitated diffusion.
Absorption of the majority of nutrients takes place in the jejunum, with the following notable exceptions:
Each villus has a network of capillaries and fine lymphatic vessels called lacteals close to its surface. The epithelial cells of the villi transport nutrients from the lumen of the intestine into these capillaries (amino acids and carbohydrates) and lacteals (lipids). The absorbed substances are transported via the blood vessels to different organs of the body where they are used to build complex substances such as the proteins required by our body. The material that remains undigested and unabsorbed passes into the large intestine.
Digested food is now able to pass into the blood vessels in the wall of the intestine through either rugae which are considered non-permanent or temporary allowing for distention and contraction. From the plicae circulares project microscopic finger-like pieces of tissue called villi (Latin for "shaggy hair"). The individual epithelial cells also have finger-like projections known as microvilli. The functions of the plicae circulares, the villi, and the microvilli are to increase the amount of surface area available for the absorption of nutrients, and to limit the loss of said nutrients to intestinal fauna.
- Proteins are degraded into small peptides and amino acids before absorption. Chemical breakdown begins in the stomach and continues in the small intestine. Proteolytic enzymes, including trypsin and chymotrypsin, are secreted by the pancreas and cleave proteins into smaller peptides. Carboxypeptidase, which is a pancreatic brush border enzyme, splits one amino acid at a time. Aminopeptidase and dipeptidase free the end amino acid products.
- Lipids (fats) are degraded into fatty acids and glycerol. Pancreatic lipase breaks down triglycerides into free fatty acids and monoglycerides. Pancreatic lipase works with the help of the salts from the bile secreted by the liver and stored in the gall bladder. Bile salts attach to triglycerides to help emulsify them, which aids access by pancreatic lipase. This occurs because the lipase is water-soluble but the fatty triglycerides are hydrophobic and tend to orient towards each other and away from the watery intestinal surroundings. The bile salts emulsify the triglycerides in the watery surroundings until the lipase can break them into the smaller components that are able to enter the villi for absorption.
- Some carbohydrates are degraded into simple sugars, or monosaccharides (e.g., glucose). Pancreatic amylase breaks down some carbohydrates (notably starch) into oligosaccharides. Other carbohydrates pass undigested into the large intestine and further handling by intestinal bacteria. Brush border enzymes take over from there. The most important brush border enzymes are dextrinase and glucoamylase which further break down oligosaccharides. Other brush border enzymes are maltase, sucrase and lactase. Lactase is absent in most adult humans and for them lactose, like most poly-saccharides, are not digested in the small intestine. Some carbohydrates, such as cellulose, are not digested at all, despite being made of multiple glucose units. This is because the cellulose is made out of beta-glucose, making the inter-monosaccharidal bindings different from the ones present in starch, which consists of alpha-glucose. Humans lack the enzyme for splitting the beta-glucose-bonds, something reserved for herbivores and bacteria from the large intestine.
The small intestine is where most chemical digestion takes place. Many of the digestive enzymes that act in the small intestine are secreted by the pancreas and enter the small intestine via the pancreatic duct. Pancreatic enzymes and bile from the gallbladder enter the small intestine in response to the hormone cholecystokinin, which is produced in the small intestine in response to the presence of nutrients. Secretin, another hormone produced in the small intestine, causes additional effects on the pancreas, where it promotes the release of bicarbonate into the duodenum in order to neutralize the potentially harmful acid coming from the stomach.
Food from the stomach is allowed into the duodenum through the pylorus by a muscle called the pyloric sphincter.
The small intestine develops from the midgut of the primitive gut tube. By the fifth week of embryological life, the ileum begins to grow longer at a very fast rate, forming a U-shaped fold called the primary intestinal loop. The loop grows so fast in length that it outgrows the abdomen and protrudes through the umbilicus. By week 10, the loop retracts back into the abdomen. Between weeks six and ten the small intestine rotates anticlockwise, as viewed from the front of the embryo. It rotates a further 180 degrees after it has moved back into the abdomen. This process creates the twisted shape of the large intestine.
|serosa||1st part serosa, 2nd–4th adventitia||normal||normal|
|muscularis externa||longitudinal and circular layers, with Auerbach's (myenteric) plexus in between||same as duodenum||same as duodenum|
|submucosa||Brunner's glands and Meissner's (submucosal) plexus||no BG||no BG|
|mucosa: muscularis mucosae||normal||normal||normal|
|mucosa: lamina propria||no PP||no PP||Peyer's patches|
|mucosa: intestinal epithelium||simple columnar. Contains goblet cells, Paneth cells||Similar to duodenum||?|
The three sections of the small intestine look similar to each other at a microscopic level, but there are some important differences. The parts of the intestine are as follows: