Small temporal RNA

Small temporal RNA

Small temporal RNA (abbreviated stRNA) regulates gene expression during roundworm development by preventing the mRNAs they bind from being translated.[1] In contrast to siRNA, stRNAs downregulate expression of target RNAs after translation initiation without affecting mRNA stability.[2] Nowadays, stRNAs are better known as miRNAs.

stRNAs exert negative post-transcriptional regulation by binding to complementary sequences in the 3' untranslated regions of their target genes. stRNAs are transcribed as longer precursor RNAs that are processed by the RNase

  1. ^ Science, vol. 293, no. 5531, pp. 811-813 (August 3, 2001).
  2. ^ Grosshans H, Slack FJ (2002). "Micro-RNAs : small is plentiful". J Cell Biol 156 (1): 17–22.  
  3. ^ Banerjee D, Slack F (February 2002). "Control of developmental timing by small temporal RNAs: a paradigm for RNA-mediated regulation of gene expression". Bioessays 24 (2): 119–29.