Somatostatin receptor 2

Somatostatin receptor 2
SSTR2 Gene
RNA expression pattern

Somatostatin receptor type 2 is a protein that in humans is encoded by the SSTR2 gene.[1]

Somatostatin acts at many sites to inhibit the release of many hormones and other secretory proteins. The biologic effects of somatostatin are probably mediated by a family of G protein-coupled receptors that are expressed in a tissue-specific manner. SSTR2 is a member of the superfamily of receptors having seven transmembrane segments and is expressed in highest levels in cerebrum and kidney.[2]


Somatostatin receptor 2 has been shown to interact with SHANK2.[3]

Therapeutic targeting

Most pituitary adenomas express SSTR2, but other somatostatin receptors are also found.<[4] Somatostatin analogs (i.e. Octreotide, Lanreotide ) are used to stimulate this receptors, and thus to inhibit further tumor proliferation.[5]

See also


Further reading

External links

  • Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.