|Jmol-3D images||Image 1|
|Molar mass||302.45 g/mol|
|Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)|
The route used to prepare the unsaturated 2 methyl androgen stenbolone provides yet a further illustration of the propensity for the formation of enolates at the 2 position.
Thus reaction of dihydrotestosterone acetate with formaldehyde and dimethylamine gives the Mannich product. Hydrogenolysis of that product gives the 2-methyl derivative via elimination of dimethylamine. Bromination of the ketone leads to the 2-bromo derivative. Dehydrobromination by means of lithium carbonate in dimethyl formamide (DMF) affords the androgen stenbolone acetate.