Sulbactam
Systematic (IUPAC) name
(2S,5R)-3,3-Dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid 4,4-dioxide
Clinical data
AHFS/Drugs.com
MedlinePlus
Legal status
Routes of
administration
Injection
Pharmacokinetic data
Bioavailability 1
Excretion Kidneys?
Identifiers
CAS Registry Number  YesY
ATC code J01
PubChem CID:
ChemSpider  YesY
UNII  YesY
KEGG  YesY
ChEBI  YesY
ChEMBL  YesY
Chemical data
Formula C8H11NO5S
Molecular mass
Documentation

 YesY   

Sulbactam is a β-lactamase inhibitor. This drug is given in combination with β-lactam antibiotics to inhibit β-lactamase, an enzyme produced by bacteria that destroys the antibiotics. [1]

Mechanism

Sulbactam is an irreversible inhibitor of β-lactamase; it binds to the enzyme and does not allow it to degrade the antibiotic.

Uses

Sulbactam is able to inhibit the most common forms of β-lactamase but is not able to interact with the ampC cephalosporinase. Thus, it confers little protection against bacteria such as Pseudomonas aeruginosa, Citrobacter, Enterobacter, and Serratia, which often express this gene.

In the United States, sulbactam is combined to form cefoperazone/sulbactam and ampicillin/sulbactam. It does possess some antibacterial activity when administered alone, but it is too weak to have any clinical importance. Its use in the UK is restricted to hospitals.

Recently, its use in treating Acinetobacter septicemia is receiving renewed interest.

See also

References

  1. ^

Further reading