Tiletamine

Tiletamine

Tiletamine
Systematic (IUPAC) name
2-ethylamino-2-(2-thienyl) cyclohexanone
Clinical data
AHFS/Drugs.com
Legal status
Routes of
administration
IV, IM, SC, Other
Pharmacokinetic data
Metabolism Liver
Excretion Kidneys
Identifiers
CAS Registry Number  N
ATC code None
PubChem CID:
ChemSpider  YesY
UNII  YesY
KEGG  YesY
Chemical data
Formula C12H17NOS
Molecular mass
Documentation

 N   

Tiletamine is a dissociative anesthetic and pharmacologically classified as an NMDA receptor antagonist.[1] It is related chemically to ketamine.[2] Tiletamine hydrochloride exists as odourless white crystals.

It is used in veterinary medicine in the compound product Telazol (tiletamine/zolazepam, 50 mg/ml of each in 5 ml vial) as an injectable anesthetic for use in cats and dogs.[3][4][5] It is sometimes used in combination with xylazine (Rompun) to tranquilize large mammals such as polar bears[6] and wood bison.[7] Telazol is the only commercially available tiletamine product in the United States. It is contraindicated in patients of an ASA score of III or greater and in animals with CNS signs, hyperthyroidism, cardiac disease, pancreatic or renal disease, pregnancy, glaucoma, or penetrating eye injuries.[3]

Abuse of Telazol has been documented.[8] Animal studies have also shown that tiletamine produces rewarding and reinforcing effects.[9] Tiletamine products are classified as Schedule III controlled substances in the United States.[10]

See also

References

  1. ^
  2. ^ NIH Pubchem entry for Tiletamine
  3. ^ a b
  4. ^ Lin HC, Thurmon JC, Benson GJ, Tranquilli WJ. Telazol: a review of its pharmacology and use in veterinary medicine. J Vet Pharmacol Ther. 1993 Dec;16(4):383-418. Review. PMID 8126757
  5. ^ NIH Tiletamine entry in Toxnet Page last reviewed 1/21/2009
  6. ^
  7. ^
  8. ^
  9. ^ http://www.ncbi.nlm.nih.gov/pubmed/22659394
  10. ^

External links

  • Erowid: Telazol