Zinc-activated ion channel

Zinc-activated ion channel

Zinc activated ligand-gated ion channel
Symbols  ; L2; LGICZ; LGICZ1; ZAC; ZAC1
External IDs IUPHAR: ChEMBL: GeneCards:
Species Human Mouse
Entrez n/a
Ensembl n/a
UniProt n/a
RefSeq (mRNA) n/a
RefSeq (protein) n/a
Location (UCSC) n/a
PubMed search n/a

Zinc-activated ion channel (ZAC), is a human protein encoded by the ZACN gene. ZAC forms a cation-permeable ligand-gated ion channel of the "Cys-loop" superfamily. The ZAC gene is present in humans and dogs, but no ortholog is thought to exist in the rat or mouse genomes.[1]

ZAC mRNA is expressed in prostate, thyroid, trachea, lung, brain (adult and fetal), spinal cord, skeletal muscle, heart, placenta, pancreas, liver, kidney and stomach.[1][2] The endogenous ligand for ZAC is thought to be Zn2+, although ZAC has also been found to activate spontaneously. The function of spontaneous ZAC activation is unknown.[1]


  1. ^ a b c Davies PA, Wang W, Hales TG, Kirkness EF (2003). "A novel class of ligand-gated ion channel is activated by Zn2+". J Biol. Chem. 278 (2): 712–7.  
  2. ^ Houtani T, Munemoto Y, Kase M, Sakuma S, Tsutsumi T, Sugimoto T (2005). "Cloning and expression of ligand-gated ion-channel receptor L2 in central nervous system". Biochem Biophys Res Commun 335 (2): 227–85.